Chord Label Personalization through Deep Learning of Integrated Harmonic Interval-based Representations

The increasing accuracy of automatic chord estimation systems, the availability of vast amounts of heterogeneous reference annotations, and insights from annotator subjectivity research make chord label personalization increasingly important. Nevertheless, automatic chord estimation systems are historically exclusively trained and evaluated on a single reference annotation. We introduce a first approach to automatic chord label personalization by modeling subjectivity through deep learning of a harmonic interval-based chord label representation. After integrating these representations from multiple annotators, we can accurately personalize chord labels for individual annotators from a single model and the annotators' chord label vocabulary. Furthermore, we show that chord personalization using multiple reference annotations outperforms using a single reference annotation.Comment: Proceedings of the First International Conference on Deep Learning and Music, Anchorage, US, May, 2017 (arXiv:1706.08675v1 [cs.NE]

Thoracic and lumbar vertebral bone mineral density changes in a natural occuring dog model of diffuse idiopathic skeletal hyperostosis

Ankylosing spinal disorders can be associated with alterations in vertebral bone mineral density (BMD). There is however controversy about vertebral BMD in patients wuse idiopathic skeletal hyperostosis (DISH). DISH in Boxer dogs has been considered a natural occurring disease model for DISH in people. The purpose of this study was to compare vertebral BMD between Boxers with and without DISH. Fifty-nine Boxers with (n=30) or without (n=29) DISH that underwent computed tomography were included. Vertebral BMD was calculated for each thoracic and lumbar vertebra by using an earlier reported and validated protocol. For each vertebral body, a region of interest was drawn on the axial computed tomographic images at three separate locations: immediately inferior to the superior end plate, in the middle of the vertebral body, and superior to the inferior end plate. Values from the three axial slices were averaged to give a mean Hounsfield Unit value for each vertebral body. Univariate statistical analysis was performed to identify factors to be included in a multivariate model. The multivariate model including all dogs demonstrated that vertebral DISH status (Coefficient 24.63; 95% CI 16.07 to 33.19; p < 0.001), lumbar vertebrae (Coefficient -17.25; 95% CI -23.42 to -11.09; p < 0.01), and to a lesser extent higher age (Coefficient -0.56; 95% CI -1.07 to -0.05; p = 0.03) were significant predictors for vertebral BMD. When the multivariate model was repeated using only dogs with DISH, vertebral DISH status (Coefficient 20.67; 95% CI, 10.98 to 30.37; p < 0.001) and lumbar anatomical region (Coefficient -38.24; 95% CI, -47.75 to -28.73; p < 0.001) were again predictors for vertebral BMD but age was not. The results of this study indicate that DISH can be associated with decreased vertebral BMD. Further studies are necessary to evaluate the clinical importance and pathophysiology of this finding

An Infrared Imaging Study of the Bipolar Proto-Planetary Nebula IRAS 16594-4656

High-resolution mid-infrared images have been obtained in N-band and Q-band for the proto-planetary nebula IRAS 16594-4656. A bright equatorial torus and a pair of bipolar lobes can clearly be seen in the infrared images. The torus appears thinner at the center than at the edges, suggesting that it is viewed nearly edge-on. The infrared lobes correspond to the brightest lobes of the reflection nebula seen in the Hubble Space Telescope (HST) optical image, but with no sign of the point-symmetric structure seen in the visible image. The lobe structure shows a close correspondence with a molecular hydrogen map obtained with HST, suggesting that the dust emission in the lobes traces the distribution of the shocked gas. The shape of the bipolar lobes shows clearly that the fast outflow is still confined by the remnant circumstellar envelope of the progenitor asymptotic giant branch (AGB) star. However, the non-detection of the dust outside of the lobes suggests that the temperature of the dust in the AGB envelope is too low for it to be detected at 20 microns.Comment: Accepted by the Astrophysical Journa

Clinical and magnetic resonance imaging characteristics of thoracolumbar intervertenral disk extrusions and protrusions in large breed dogs

It has recently been shown that the fat-derived hormone adiponectin has the ability to decrease hyperglycemia and to reverse insulin resistance. However, bacterially produced full-length adiponectin is functionally inactive. Here, we show that endogenous adiponectin secreted by adipocytes is post-translationally modified into eight different isoforms, as shown by two-dimensional gel electrophoresis. Carbohydrate detection revealed that six of the adiponectin isoforms are glycosylated. The glycosylation sites were mapped to several lysines (residues 68, 71, 80, and 104) located in the collagenous domain of adiponectin, each having the surrounding motif of GXKGE(D). These four lysines were found to be hydroxylated and subsequently glycosylated. The glycosides attached to each of these four hydroxylated lysines are possibly glucosylgalactosyl groups. Functional analysis revealed that full-length adiponectin produced by mammalian cells is much more potent than bacterially generated adiponectin in enhancing the ability of subphysiological concentrations of insulin to inhibit gluconeogenesis in primary rat hepatocytes, whereas this insulin-sensitizing ability was significantly attenuated when the four glycosylated lysines were substituted with arginines. These results indicate that full-length adiponectin produced by mammalian cells is functionally active as an insulin sensitizer and that hydroxylation and glycosylation of the four lysines in the collagenous domain might contribute to this activity.link_to_subscribed_fulltex

B-type anomaly coefficients for the D3-D5 domain wall

We compute type-B Weyl anomaly coefficients for the domain wall version of N = 4 SYM that is holographically dual to the D3-D5 probe-brane system with flux. Our starting point is the explicit expression for the improved energy momentum tensor of N = 4 SYM. We determine the two-point function of this operator in the presence of the domain wall and extract the anomaly coefficients from the result. In the same process we determine the two-point function of the displacement operator.Comment: 6 page

High Energy Neutrinos from Cosmic Ray Interactions in Clusters of Galaxies

The spatial clustering of galaxies in galaxy clusters implies that the background of infrared (IR) light in the intracluster medium (ICM) may exceed the universal background. Cosmic rays injected within the ICM propagate diffusively and at low enough energies are trapped there for cosmological times. The photopion production interactions of cosmic rays with the IR photons are responsible for the generation of neutrinos whose detection may shed some light on the origin and propagation of high energy cosmic rays in the universe. Here we discuss our calculations of the flux of neutrinos from single clusters as well as the contribution of photopion production in clusters of galaxies to the diffuse neutrino background.Comment: 10 pages, 10 figures, submitted to PR